The nightlife in Prague is not on the same level as one might find in Paris or London, but it does have its share of pomp and circumstance.
Clubbing in Prague has a flavor of its own. In many places, it makes no difference what you wear as there is no strict dress code. The Lucerna music bar, for example, is frequented by a relaxed local crowd with a fondness for music from the 80s and 90s. The dress code is casual and the locals are warm, friendly, and enthusiastic.
Off the beaten track from the regular discos are the jazz and blues bars. These are generally small venues that make up for their limited proportions with appropriate décor and great music.
Another interesting bar with a twist is a combination bar and library. Shakespeare & Sons serves expensive beer and cheap red wine to literary enthusiasts and intellectuals. The bar is attached to a bookshop where customers can browse through the racks of old and new books. Live music is also available here. Every alternate Wednesday is amateur night, where anyone with rudimentary guitar skills can show off their talent.
Pub lovers may want to try out famous Prague author Bohumil Hrabal's favorite pub-U Zlateho Tygra. The atmosphere is loud and rowdy and the beer is served in copious amounts throughout the night to patrons seated at the long wooden tables.
The city also caters to gamblers via the Hilton hotel, whose basement casino is reportedly open from 2 pm to 6 am. A buffet is provided for hungry guests until 9 pm.
For a quieter evening watching TV, enjoying a few drinks, and/or listening to some good music, a venue like “Joe's Café" in Wenceslas Square, provides a great bar, well trained staff, and great food and drink.
For the more genteel crowd, a sophisticated cocktail bar may be more their cup of tea. These generally cater to the see-and-be-seen crowd and are tastefully decorated. There is music and dancing for those interested in working up a sweat, but the tone of the evening is infinitely quieter than the boisterous reveling in the pubs.
To get away from the noise for a bit, take an evening walk through Old Town or Charles Bridge or stroll down the banks of the river to watch the brightly lit cruise boats go by. In the end, moments like these will likely become one's most memorable experiences of Prague nightlife.