Already on ArticleSlash?

Forgot your password? Sign Up

Calculating The Probability Of A Biological Relationship

 


Visitors: 189

While the average customer understands that DNA paternity test results are delivered according to percentages (e. g. a 99% or 0% likelihood of paternity), the question often remains, How accurate are these numbers?

The Paternity Index for each child-father match represents the likelihood of paternity versus a random man of similar ethnic background. DNA Worldwide calculates the Paternity Index using the putative father’s ethnicity and allele frequencies for the matching allele.

If the matching alleles are relatively uncommon, the Paternity Index will be high, providing the strongest evidence of a paternal relationship. Where matching alleles are among the most common, the Paternity Index will be lower, suggesting the possibility of random matching between unrelated individuals; such correlations are much weaker.

Once the Paternity Index has been generated for each matching allele, the Combined Paternity Index is calculated by multiplying all Paternity Indices together.

A result that exceeds 100 indicates a 99% or greater probability that the man is the child’s biological father. Paternity test CPI values can extend into the millions, yielding paternity probabilities of 99.9999% and higher.

Even a single mismatch will result in a CPI of 0—generally excluding the possibility of fatherhood in the putative individual; two or more mismatches add certainty to this exclusion.

However, in some rare circumstances one—or more—mismatches could still permit inclusion of the purported father as the biological father. Occasionally a natural mutation can occur through which a child’s allele will differ from that of his father. For example, a father may possess alleles measuring 10 and 12 at a particular marker, but through mutation, he might pass an 11 or a 13 to his child (mutations tend to move in single steps from original alleles—generally in an upward direction).

In the rare case in which an alleged father matches at all other loci—with the mismatch differing by a single step—DNA Worldwide performs additional analysis to verify the likelihood of this difference being a true mismatch, versus the result of a mutation. In such cases, DNA Worldwide consults special databases that store mutation rates and allele frequencies. Additionally, DNA Worldwide may perform other DNA testing to confirm the mutation or mismatch. Once completed, DNA Worldwide offers a twice-tested, double-checked result; this is the percentage of probability that the consumer is hoping to see.

Terrence Ogden is an investigative writer. For more information on Terrence Ogden is an investigative writer. For more information on DNA paternity testing in UK or /FREE-DNA-Test-Kit DNA testing kits, he recommends you to visit

(437)

Article Source:


 
Rate this Article: 
 
Sleep and Our Biological Clock
Rated 4 / 5
based on 5 votes
ArticleSlash

Related Articles:

Probability Waves

by: Joseph Rettig (August 06, 2008) 
(Self Improvement/Attraction)

Law Of Probability And Manifestation Success

by: Enoch Tan (June 27, 2007) 
(Self Improvement/Attraction)

Reduce the Probability of Getting Picked Up

by: Steve Thibeault (August 07, 2008) 
(News/Crime)

10 Times the Probability of Succeeding by Writing it Down

by: Mark A. Singh (April 01, 2008) 
(Self Improvement/Goal Setting)

Math Help for Those Struggling with Probability, Statistics or Calculus

by: Ann R Knapp (December 01, 2007) 
(Reference and Education)

Fibonacci Trading, Your Compass To High Probability Trades

by: Adrian Pablo (January 10, 2007) 
(Finance)

A Cancer Survivor Story - Increase Your Probability Of Success

by: Gregory Drambour (January 28, 2008) 
(Cancer)

How to Look Younger Than Your Biological Age

by: Kyle J Norton (July 27, 2008) 
(Health and Fitness/Anti Aging)

Calculating Net Asset Value

by: Pauline Go (February 11, 2008) 
(Investing)

Sleep and Our Biological Clock

by: Finetea Shine (April 15, 2011) 
(Health and Fitness/Sleep Snoring)