Already on ArticleSlash?

Forgot your password? Sign Up

Zyprexa: Anatomy Of A Drug's Side Effects

 


Visitors: 342

Zyprexa is an antipsychotic drug used for the treatment of bipolar disorder and schizophrenia. It is also known as Olanzapine (generic form) and under the trade names Zalasta, Zypadhera, Zolafren Oferta and Olzapin. Pharmaceutical giant Eli Lilly manufactures the drug and the patent will expire in 2011. It was approved by the FDA for the treatment of manifestations of psychotic disorders, bipolar disorder depressive episodes and for long-term bipolar disorder treatment.

Common Forms and Dosage of Zyprexa

Zyprexa is available in three forms: tablets, disintegrating wafers and intramuscular injection. Tablets come in six dosage strengths ranging from 2.5 mg to 20 mg. Wafers range in strength from 5 mg to 20 mg and intramuscular injections intended for short-term use come in 10 mg strength. The dosage depends upon the patient’s medical issues and drug response.

How Zyprexa Works in the Body

As with many of the atypical antipsychotics, Zyprexa affects the dopamine receptors and has a low affinity for alpha adrenergic, cholinergic muscarinic and histamine receptors. Zyprexa’s sedating properties may be contributed to by its weak affinity for the GABA , BZD receptor area. AlthoughZyprexa’s mode of action on antipsychotic activity still isn’t known, it is possible that it involves antagonism at the serotonin receptors as well. However, antagonism at the dopamine receptors can cause extrapyramidal effects like tardive dyskinesia along with any therapeutic effects.

Side Effects of Zyprexa

Zyprexa, as with most antipsychotics, has a long list of side effects and adverse reactions. These include:

Minor Side Effects of Zyprexa

  • Dry Mouth
  • Runny Nose
  • Irritability
  • Weight gain
  • Increased appetite
  • Constipation
  • Missed periods
  • Apathy

Major Side Effects

  • Akathisia
  • Sedation
  • Insomnia
  • Urinary retention
  • Impaired judgment, motor skills and thinking
  • Orthostatic hypotension
  • Impaired spatial orientation
  • Seizures
  • Trouble swallowing
  • Impaired spatial orientation
  • Dental problems including teeth discoloration
  • Difficulty regulating body temperature
  • Brain Zaps
  • Endocrine system side effects, including hyperglycemia, diabetes mellitus and hyperprolactinemia
  • Auditory hallucinations

Diabetes has been a very serious concern in users of Zyprexa and for good reason. Zyprexa has been linked to a total of 288 cases of Zyprexa induced diabetes, which includes 23 deaths. In fact, the concern was so serious that the European Union and Japan both now require that Zyprexa labeling contain a diabetes warning.

Other than diabetes, hyperglycemia and ketoacidosis are also concerns. In fact, in nearly 50% of ketoacidosis reports caused by Zyprexa, the results are fatal.

Several lawsuits have been filed against Eli Lilly suggesting that the company has attempted to hide the dangers associated with their best selling drug for schizophrenia. The health risks associated with Zyprexa that have resulted in lawsuits are typically those that have resulted from the drug’s ability to cause diabetes. However, other lawsuits have been filed against the company for additional and equally serious side effects.

The drug itself is Eli Lilly’s most popular drug and, as of the time of this writing, sales of the drug were reportedly $4.2 billion the previous year.

If you have experienced serious side effects as a result of taking Reglan, a lawyer with experience in the ongoing Zyprexa lawsuit can help evaluate your claim at no charge. The Zyprexa attorneys at JD Law Group are qualified to review your claim. You can contact them directly via 1-888-736-4248 or by filling out the contact form at the bottom of this page.

DISCLAIMER: The information provided on this website or the web site linked here in are not a substitute for professional medical or legal advice, diagnosis or treatment. In addition, viewing the content on these websites, requesting additional information, or transmitting information through a contact form does not form an attorney-client relationship with the sponsoring attorney. Any results set forth herein are based upon the facts of that particular case or scientific study and do not represent a promise or guaranty regarding similar outcome or causes. The information on this site is intended for educational purposes only and should never interfere with a patient/site visitor and his or her healthcare provider. Internet subscribers or online readers should not act upon any information contained herein without seeking professional legal and/or medical advice. This firm is licensed to practice law only in the state of California, but is affiliated with a network of licensed attorneys in other states. Call 911 for all medical emergencies. Drug-Recalls.org and JD Law Group makes no representation or warranty regarding the accuracy, reliability, completeness, currentness, or timeliness of the content, text or graphics. Links to other sites are provided for information only — they do not constitute endorsements of those other sites.

Resource : Drug-recalls is a free resource about recalled or questionable drugs. The Zyprexa-Attorneys at JD Law Group specialize in helping people seriously injured by questionable drugs like Zyprexa . For any Zyprexa - Lawsuit claim you may contact via 1-888-736-4248 or by out the contact form at the bottom of this page.

(924)

Article Source:


 
Rate this Article: 
 
Quit Smoking Side Effects What Are the Side Effects of Quitting Smoking?
Rated 4 / 5
based on 5 votes
ArticleSlash

Related Articles:

JWH-018 drug Side Effects

by: Prakash Balaji (December 20, 2010) 
(Health and Fitness/Mind Body Spirit)

Side effects of JWH-018 drug

by: Prakash Balaji (December 20, 2010) 
(Health and Fitness/Mind Body Spirit)

A Problem With Zetia: Have You Experienced Troubling Side Effects From Taking ..

by: Athlyn Green (January 25, 2007) 
(Health and Fitness)

Goldenseal - Drug Interactions, Side Effects and Precautions of Use-Herbal ..

by: Prahalad Singh (February 21, 2008) 
(Health and Fitness/Medicine)

Burdock-Drug Interactions, Side Effects and Precautions of Use-Herbal Medicines

by: Prahalad Singh (February 21, 2008) 
(Health and Fitness/Medicine)

Side Effects Of Hoodia Gordonii Plus - Discover If There Are Any Adverse Side ..

by: Sam Ayodeji (February 25, 2008) 
(Health and Fitness/Weight Loss)

Phentramin Side Effects vs Phentramine Side Effects

by: Ian Mason (January 13, 2007) 
(Health and Fitness)

Fosamax: Anatomy of A Questionable Drug

by: Jay Nr (October 08, 2011) 
(Legal/Personal Injury)

Quit Smoking Side Effects What is the Main Side Effect?

by: Ravi Oza (July 01, 2008) 
(Health and Fitness/Quit Smoking)

Quit Smoking Side Effects What Are the Side Effects of Quitting Smoking?

by: Nadine Christie (July 05, 2008) 
(Health and Fitness/Quit Smoking)