"My Doctor Wants Me to Take Enbrel For My Rheumatoid Arthritis-What Can You Tell me About it?

 


Visitors: 217

TNF alpha is a cytokine, a protein that is produced during the inflammatory response. TNF alpha is involved in inflammation from two perspectives. It is not only the product of inflammation; it also helps perpetuate and promote inflammation. Increased levels of TNF are found in several inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Drugs that block tumor necrosis factor (TNF) have been found to be particularly effective for the treatment of these serious forms of inflammatory arthritis.

The first anti-TNF drug approved for such use was etanercept (Enbrel).

Etanercept is a synthetic (man-made) protein that binds to TNF alpha. It acts like a sponge to remove most of the TNF alpha molecules from the joints and blood. This prevents TNF alpha from perpetuating inflammation and the pain, tenderness and swelling of joints in patients with different types of arthritis.

Etanercept reduces the signs and symptoms of rheumatoid arthritis, the arthritis of psoriasis, and ankylosing spondylitis. It also prevents the progression of joint destruction in patients with rheumatoid arthritis and the arthritis of psoriasis.

Etanercept is usually used in combination with methotrexate in patients who do not respond adequately to methotrexate alone.

Etanercept comes in two different preparations. The first is a powder that must be reconstituted (mixed) with a diluent. This comes as a 25 mg dose. The second is as a premixed syringe containing 50 mgs of etanercept. Etanercept must be refrigerated. The drug is given as a subcutaneous injection. Dosing will vary according to disease severity and body size.

Because etanercept reduces the immune response, it should not be administered with live vaccines. Etanercept is not recommended for use in pregnant or nursing women.

The most common side effects are mild to moderate itching, pain, swelling and redness at the site of injection. Headache, dizziness, nose and throat irritation also occur.

TNF alpha has an important role in the response of the immune system to infections. Blocking the action of TNF alpha with etanercept may worsen or increase the occurrence of infections, and patients with serious infections should not receive etanercept. Etanercept should be discontinued if a patient develops a serious infection. It should not be given to patients with active infections or who have an allergy to its components. Etanercept should be used with caution in patients prone to infection, such as those with poorly controlled diabetes.

Since etanercept has entered the market, there have been reports of multiple sclerosis, myelitis, optic neuritis in patients using the drug. Etanercept is not recommended for persons with preexisting disease of the central nervous system (brain and/or spinal cord) or for those with multiple sclerosis, myelitis, or optic neuritis. Rare cases of potentially serious low blood counts (pancytopenia) have been reported in patients using etanercept.

Monitoring should be done according to guidelines set by the rheumatologist.

Dr. Wei (pronounced “way”) is a board-certified rheumatologist and Clinical Director of the nationally respected Arthritis and Osteoporosis Center of Maryland. He is a Clinical Assistant Professor of Medicine at the University of Maryland School of Medicine and has served as a consultant to the Arthritis Branch of the National Institutes of Health. He is a Fellow of the American College of Rheumatology and the American College of Physicians. For more information on arthritis and related conditions, go to: http://www.arthritis-treatment-and-relief.com

(575)

Article Source:


 
Rate this Article: 
 
Rheumatoid Arthritis Treatment - How a Deer Can Help Rebuild Cartilage and Cure .
Rated 4 / 5
based on 5 votes
ArticleSlash

Related Articles:

Doctor, Should I Take Humira for My Rheumatoid Arthritis?

by: Nathan Wei (June 28, 2006) 
(Health and Fitness/Medicine)

My Doctor Wants Me To Start Kineret For My Rheumatoid Arthritis - What Is It?

by: Nathan Wei (October 26, 2006) 
(Health and Fitness)

Doctor... I Have Rheumatoid Arthritis - Can I Drink Alcohol?

by: Nathan Wei (December 19, 2006) 
(Health and Fitness)

Doctor, What's this I Read About Trace Metals for Rheumatoid Arthritis... Will ..

by: Nathan Wei (December 01, 2006) 
(Health and Fitness)

Doctor, I Am Treated With Rituxan For Rheumatoid Arthritis. What Is This ..

by: Nathan Wei (January 03, 2007) 
(Health and Fitness)

How You Can Beat Rheumatoid Arthritis Part 5: "Putting It Into ..

by: Nathan Wei (July 29, 2006) 
(Health and Fitness)

How You Can Beat Rheumatoid Arthritis Part 2: How Does the Damage Occur in ..

by: Nathan Wei (July 29, 2006) 
(Health and Fitness)

How You Can Beat Rheumatoid Arthritis Part 1: What is Rheumatoid Arthritis?

by: Nathan Wei (July 29, 2006) 
(Health and Fitness)

Remicade: Doctor, I Have Rheumatoid Arthritis and I Want to Know More About ..

by: Nathan Wei (July 10, 2006) 
(Health and Fitness/Medicine)

Rheumatoid Arthritis Treatment - How a Deer Can Help Rebuild Cartilage and Cure .

by: Joe Barton (August 06, 2007) 
(Health and Fitness/Arthritis)